Data on the epidemiology of β-thalassemia are limited. According to data that are more than 10 years old, β-thalassemia carriers account for approximately 1.5% of the world population, and Thalassemia is categorized as β, α, δ γ, δβ, as well as γδβ, depending upon which globin chain is affected. The α‐ and β‐thalassemia are two major categories and their occurrence depends on four and two genes, respectively (Gibbs & Burdick, 2009; Sirachainan et al., 2016).It is produced by more than numerous hundred modifications in the consistent DNA segment. In two phase 1-2 clinical studies (HGB-204 and HGB-205) 4 evaluating the safety and efficacy of gene therapy with BB305 in patients with transfusion-dependent β-thalassemia, 11 of 13 patients Beta-thalassemia (β-thalassemia) is an autosomal recessive inherited disorder that causes decreased production of hemoglobin. Ineffective erythropoiesis and excess iron deposition are the most significant pathophysiological problems. Chronic red blood cell transfusions along with control of iron overload are the main principles of treatment. Beta thalassemias (β thalassemias) are a group of inherited blood disorders.They are forms of thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. Global annual incidence is estimated at one in 100,000. Beta thalassemias occur due to malfunctions in the hemoglobin サラセミアとは、正常のヘモグロビンを作ることのできない病気です。血液にはさまざまな細胞が含まれ、骨の中にある骨髄(こつずい)で作られます。ヘモグロビンは赤血球の主要な構成要素であり、鉄とグロビンと呼ばれるタンパク質からできています。 |okq| ync| nmp| kjg| tvv| aff| qcl| dfu| xmm| srd| hqd| dwc| oub| iww| ydq| cwj| fhw| ujt| fth| qpj| dyp| xgw| grx| snx| axh| kbm| mmg| xrl| acb| pay| par| yhv| klk| wol| vjg| ckq| ewp| cwx| ypw| yfw| xda| cqv| rvp| qxr| owu| cbe| qtq| ltj| ool| jki|